This site has been created to provide information about the 3Rs principles of animal use and guide their application in wildlife research.
The Interspecies Database helps researchers to make an optimal choice of species and strain of the animal model, which is essential for efficient extrapolation of animal data to humans or other animals.
A research tissue bank (RTB) or biobank is a collection of human tissue or other biological material, which is stored for future research use. Some RTBs store samples in order to answer a very specific question about health, while others collect for future use without knowing exactly for what research projects the tissue will be used.
This 18 minute video presentation has been created by NC3Rs to serve as a foundation for this understanding, and to encourage scientists and animal technicians to consider and implement the 3Rs throughout their careers.
A detailed inventory - compiled by JRC scientists - of 800 knowledge sources relevant to the Replacement, Reduction and Refinement (Three Rs) of animal procedures used for scientific purposes.
DB-ALM dataset is a publicly accessible collection of alternative method summaries and protocols. DB-ALM focuses primarily on methods submitted to EURL ECVAM for validation, and those identified in ad hoc reviews of the literature and end-users in specific application areas between 2000 and 2019.
The QM+Emulate Organs-on-Chips Centre provides access to Emulate’s Organs-on-Chips technology to enable researchers to use Emulate’s supported organ models which include: Liver, Proximal Tubule Kidney, Lung and Intestine or develop organ models of their design to expedite their experiments.
In a detailed analysis of the scientific literature, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal models of respiratory disease (e.g. asthma, COPD).
The European Commission's Joint Research Centre (JRC) has undertaken a study to review available and emerging non-animal models in the field of breast cancer.
A guide to searching for information relating to alternative methods and 3Rs. It provides search principles and procedures, suggested search terms and user guidance together with an inventory of relevant information resources.