Question 1

NC3Rs Webinar: 3Rs advice for project licence applicants

Accepted Answer

All scientific work carried out in the UK under the Animals (Scientific Procedures) Act 1986 must be part of a programme of work authorised by a project licence. An important part of the ethical review and licensing process is ensuring that the principles of the 3Rs are robustly applied. In order to achieve this, when applying for a project licence, applicants are asked to detail how they have considered and applied the 3Rs to their research. To learn more about the 3Rs and how they can drive better science and animal welfare, view this video presentation from the NC3Rs.

https://vimeo.com/438220000

Find more 3Rs guidance for project licence applicants at nc3rs.org.uk/PPLadvice.

Question 2

The Interspecies Database

Accepted Answer

https://www.interspeciesinfo.com/

The Interspecies Database helps researchers to make an optimal choice of species and strain of the animal model, which is essential for efficient extrapolation of animal data to humans or other animals.

https://malcolm-en-gb.s3.eu-west-1.amazonaws.com/instances/hwAzJt6PVl/resources/P8pc5vf4S0/banner-2.png (mouse)

The Interspecies Database is part of the 3Rs Database Programme, together with www.humane-endpoints.info and fcs-free.org. These websites will help you with the refinement and replacement of animal experiments, respectively.

Question 3

Focus and facts on the 3Rs

Accepted Answer

The Swedish 3Rs have a page with lots of multimedia resources on the 3Rs, including articles, films, and interviews.

They produce short pedagogic films about how advanced cell models and computer models can be used to replace and reduce animal experimentation.

jordbruksverket.se/languages/english/the-swedish-3rs-center/focus-and-facts

Question 4

3Rs Principles in Wildlife Research

Accepted Answer

3rswildlife.info

This site has been created to provide information about the 3Rs principles of animal use and guide their application in wildlife research. It contains examples of peer-reviewed studies that implemented non-lethal or non-invasive methods and that could be used as guidance. It is the first online resource of its kind developed specifically for wildlife biologists, ecologists, and conservation managers.

Question 5

NC3Rs introductory training video on the 3Rs

Accepted Answer

Any aspiring in vivo researcher or animal technician should have a firm understanding of how following the principles of the 3Rs can drive better science and improved animal welfare.

This 18 minute video presentation has been created by NC3Rs to serve as a foundation for this understanding, and to encourage scientists and animal technicians to consider and implement the 3Rs throughout their careers.

It is also an excellent primer for anyone interested to learn more about the 3Rs in principle and practice.

The video includes:

Definitions and explanations of each of the 'Rs'
Practical advice on how to implement the 3Rs throughout a research project
Video case studies of 3Rs research
Information on the various resources the NC3Rs provides to support anyone working with animals in research

https://vimeo.com/289645718

Demonstrating the 3Rs in principle and practice. nc3rs.org.uk

Question 6

EURL ECVAM Database Service on Alternative Methods to Animal Experimentation (DB-ALM)

Accepted Answer

http://cidportal.jrc.ec.europa.eu/ftp/jrc-opendata/EURL-ECVAM/datasets/DBALM/LATEST/online/dbalm.html

DB-ALM dataset is a publicly accessible collection of alternative method summaries and protocols. DB-ALM focuses primarily on methods submitted to EURL ECVAM for validation, and those identified in ad hoc reviews of the literature and end-users in specific application areas between 2000 and 2019.

All method summaries and protocols can be searched in an intuitive web interface and then retrieved individually, but they can also be downloaded completely for flexible perusal on a local PC. Search criteria include topic areas, biological endpoints, experimental systems, and others.

Question 7

QM+Emulate Organs-on-Chips Centre

Accepted Answer

www.cpm.qmul.ac.uk/emulate

The QM+Emulate Organs-on-Chips Centre provides access to Emulate’s Organs-on-Chips technology to enable researchers to use Emulate’s supported organ models which include: Liver, Proximal Tubule Kidney, Lung and Intestine or develop organ models of their design to expedite their experiments. Expert staff are on hand to support with training and use of the platform. The Centre also provides opportunities for collaboration with Emulate and support for commercialisation and translational impact.