Question 1

Mouse Genome Informatics

Accepted Answer

MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. The projects contributing to this resource are:

Mouse Genome Database (MGD) Project - MGD includes data on gene characterization, nomenclature, mapping, gene homologies among vertebrates, sequence links, phenotypes, allelic variants and mutants, and strain data. See About MGD.
Gene Expression Database (GXD) Project - GXD integrates different types of gene expression information from the mouse and provides a searchable index of published experiments on endogenous gene expression during development. See Gene Expression Database (GXD) and About the Gene Expression Database (GXD).
Mouse Models of Human Cancer database (MMHCdb) Project - MMHCdb integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, emphasizing data on tumors that develop characteristically in different genetically defined strains of mice. See Mouse Models of Human Cancer database and Mouse Models of Human Cancer database User Help Reference.
Gene Ontology (GO) Project at MGI - The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium (www.geneontology.org). MGI fully incorporates the GO in the database and provides a GO browser. See Functional Annotation using the Gene Ontology (GO) and The Gene Ontology (GO) Project.
Cre Resources (CrePortal) Project - The CrePortal Project collects and annotates and integrates expression and activity data for recombinase-containing transgenes and knock-in alleles. See the Recombinase Portal.
MouseMine Project - MouseMine is a powerful new system for accessing MGI data, using the InterMine framework. As a member of the InterMOD consortium, the MouseMine project also represents a new mechanism for cooperation between MGI and other MODs. See MouseMine, About the MouseMine data warehouse resource, and InterMine.
Alliance of Genome Resources - The Alliance's goal is to provide a consistent user interface with an integrated view of data from 6 Model Organism Databases and the GO Consortium. See Alliance of Genome Resources and About The Alliance.

Credit: informatics.jax.org

Question 2

Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report

Accepted Answer

Genetic quality assurance (QA), including genetic monitoring (GeMo) of inbred strains and background characterization (BC) of genetically altered (GA) animal models, should be an essential component of any QA programme in laboratory animal facilities. Genetic quality control is as important for ensuring the validity of the animal model as health and microbiology monitoring are. It should be required that studies using laboratory rodents, mainly mice and rats, utilize genetically defined animals. This paper, presented by the FELASA Working Group on Genetic Quality Assurance and Genetic Monitoring of Laboratory Murines, describes the objectives of and available methods for genetic QA programmes in rodent facilities. The main goals of any genetic QA programme are: (a) to verify the authenticity and uniformity of inbred stains and substrains, thus ensuring a genetically reliable colony maintenance; (b) to detect possible genetic contamination; and (c) to precisely describe the genetic composition of GA lines. While this publication focuses mainly on mouse and rat genetic QA, the principles will apply to other rodent species some of which are briefly mentioned within the context of inbred and outbred stocks.

DOI: 10.1177/0023677219867719

Mouse Genome Informatics

Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report

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