SIRF: Sex Inclusive Research Framework

An evaluation framework to assess whether an in vivo research proposal follows the sex inclusive research philosophy.

This framework consists of a decision tree comprising of twelve questions and associated supporting information for each question. The decision tree leads to an evaluation outcome which includes colour-coded, outcomes:

  • Green: Proposal is appropriate
  • Amber: Caution is required (i.e., the proposed design/analysis carries some risk)
  • Red: Justification for single sex study in the proposal is not sufficient
Thumbs up, palm, thumbs down

References cited in the advice that accompanies each question can be found in the Full SIRF Supporting Document using the corresponding number, e.g. [1].

For full guidance on the framework please visit openinnovation.astrazeneca.com/preclinical-research/sex-inclusive-research-framework.

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