In a detailed analysis of the scientific literature, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal models of respiratory disease (e.g. asthma, COPD).
From this, a total of 284 publications were identified as the most representative and innovative models according to a set of inclusion/exclusion criteria. In vitro cell and tissue cultures, human ex vivo, in silico approaches were chiefly considered.
The result is a unique highly curated knowledge base containing detailed descriptions of non-animal models being used for respiratory disease research, including information on their applications and biological relevance.
It is freely available in an easy-to-use spreadsheet format from the EURL ECVAM Collection in the JRC Data Catalogue.